Perianal and anal canal neoplasms are relatively uncommon. Cancer of the anal canal
constitutes 1.5% of gastrointestinal neoplasms in the United States, with approximately
3900 cases predicted for 2002 [
[1]
]. The varied histology of the anal canal and anal verge give rise to a wide spectrum
of malignant and premalignant diseases. Fortunately, most are curable by either primary
chemoradiation or local excision, allowing sphincter preservation in the majority
of patients. Such is not the case for anorectal melanoma, which continues to have
a guarded prognosis despite aggressive surgical therapy. The optimal treatment for
other relatively rare anal neoplasms, such as anal adenocarcinoma, remains unclear.
In this article, we review the various neoplasms that affect the anal canal and anal
margin, focusing on diagnosis, therapy, and outcome.To read this article in full you will need to make a payment
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© 2002 Elsevier Science (USA). Published by Elsevier Inc. All rights reserved.
