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Melanoma has one of the fastest rising frequency among all cancers in North America. The current understanding of the risk factors and epidemiology of melanoma is discussed by Dr Wernberg and colleagues.
The knowledge of the genetic basis of melanoma has improved significantly even since the last issue in 2014. Dr Abdo explores the increased understanding of role of hereditary and association with other potentially fatal visceral malignancies.
The staging of melanoma has evolved after the publication of the American Joint Committee on Cancer, 8th manual. Dr Allamaneni discusses this change along with the potential for therapeutic implications.
Dr Chopra describes the current understanding of the histologic and molecular pathology of melanoma.
Despite the advances in the management of advanced disease, most melanomas are still cured by surgery. Dr Skitzki explains the role of surgery in the treatment of primary melanoma.
The management of lymph nodal basin at risk has changed after the publication of MSLT II and the DeCoG SLT trials. Dr Francescutti discusses the surgical and nonsurgical options for management of nodal stations.
Dr Zager describes options for locoregionally advanced melanoma, including role of oncolytic viral therapy.
Surgery still has a role in appropriately selected patients with metastatic melanoma, as described by Dr Votanopoulos.
Dr Delman discusses the implications of systemic therapy for melanoma in the surgical management.
Dr Onitilo and Khushlani introduce the principles of immunotherapy and targeted therapy for the practicing surgeons.
The role of radiation therapy in melanoma in the era of effective systemic therapy is evolving, as discussed by Dr Prashar.
Finally, Dr Sarkisian describes the ongoing clinical trials of advanced melanoma.
In the era of rapidly changing landscape of melanoma management, a multidisciplinary approach has become an essential component to optimize the care of our patients. I am thankful to all the colleagues who have taken time out of their incredibly busy schedules to provide insights about melanoma treatment and to contribute to this issue. It is my hope that the medical student and surgical community will find this issue useful for making patient care decisions. I am grateful to Dr Martin for giving me the opportunity to put this issue together, and to editorial staff at Elsevier for their assistance.