Review Article| Volume 102, ISSUE 2, P325-333, April 2022

Management of Malignant Salivary Gland Conditions


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.


      Subscribe to Surgical Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • American Cancer Society
        Salivary gland cancer.
        (Available at:) (Accessed May 31, 2021)
        • Carvalho A.L.
        • Nishimoto I.N.
        • Califano J.A.
        • et al.
        Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database.
        Int J Cancer. 2005; 114: 806-816
        • Guzzo M.
        • Locati L.D.
        • Prott F.J.
        • et al.
        Major and minor salivary gland tumors.
        Crit Rev Oncol Hematol. 2010; 74: 134-148
        • Waldron C.A.
        • el-Mofty S.K.
        • Gnepp D.R.
        Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases.
        Oral Surg Oral Med Oral Pathol. 1988; 66: 323-333
        • Witt R.
        Surgery of the salivary glands.
        Springer, Switzerland2020
        • Stodulski D.
        • Mikaszewski B.
        • Stankiewicz C.
        Signs and symptoms of parotid gland carcinoma and their prognostic value.
        Int J Oral Maxillofac Surg. 2012; 41: 801-806
        • Lanišnik B.
        • Levart P.
        • Čizmarevič B.
        • et al.
        Surgeon-performed ultrasound with fine-needle aspiration biopsy for the diagnosis of parotid gland tumors.
        Head Neck. 2021; 43: 1739-1746
        • El Kininy W.
        • Roddy D.
        • Davy S.
        • et al.
        Magnetic resonance diffusion weighted imaging using constrained spherical deconvolution-based tractography of the extracranial course of the facial nerve.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2020; 130: e44-e56
        • Boldes T.
        • Hilly O.
        • Alkan U.
        • et al.
        Accuracy, predictability and prognostic implications of fine-needle aspiration biopsy for parotid gland tumours: a retrospective case series.
        Clin Otolaryngol. 2021;
        • Reerds S.T.H.
        • Van Engen-Van Grunsven A.C.H.
        • van den Hoogen F.J.A.
        • et al.
        Accuracy of parotid gland FNA cytology and reliability of the Milan System for reporting salivary gland cytopathology in clinical practice.
        Cancer Cytopathol. 2021;
        • Stewart C.J.
        • MacKenzie K.
        • McGarry G.W.
        • et al.
        Fine-needle aspiration cytology of salivary gland: a review of 341 cases.
        Diagn Cytopathol. 2000; 22: 139-146<139::aid-dc2>;2-a
        • Feinstein A.J.
        • Alonso J.
        • Yang S.E.
        • et al.
        Diagnostic accuracy of fine-needle aspiration for parotid and submandibular gland lesions.
        Otolaryngology--head neck Surg. 2016; 155: 431-436
        • Pusztaszeri M.
        • Rossi E.D.
        • Baloch Z.W.
        • et al.
        Salivary gland fine needle aspiration and introduction of the milan reporting system.
        Adv Anat Pathol. 2019; 26: 84-92
        • Mullen D.
        • Gibbons D.
        A retrospective comparison of salivary gland fine needle aspiration reporting with the Milan system for reporting salivary gland cytology.
        Cytopathology. 2020; 31: 208-214
        • Carlson E.R.
        • Schlieve T.
        Salivary gland malignancies.
        Oral Maxillofac Surg Clin North Am. 2019; 31: 125-144
        • Zarbo R.J.
        Salivary gland neoplasia: a review for the practicing pathologist.
        Mod Pathol. 2002; 15: 298-323
      1. El-Naggar AK, Chan JKC, Rubin Grandis J, et al, International Agency for Research on C. WHO classification of head and neck tumours. 2017.

        • Kim H.J.
        • Kim J.S.
        Ultrasound-guided core needle biopsy in salivary glands: a meta-analysis.
        Laryngoscope. 2018; 128: 118-125
      2. Amin M.B. Edge S. Greene F. AJCC cancer staging manual. 8th edition. Springer International Publishing: American Joint Commission on Cancer, 2017
      3. Survival rates for salivary gland cancer.
        (Available at:)
        • Jang J.Y.
        • Choi N.
        • Ko Y.H.
        • et al.
        Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1-2 N0 high-grade salivary gland cancer.
        BMC Cancer. 2018; 18: 672
        • Melo G.M.
        • Cervantes O.
        • Abrahao M.
        • et al.
        A brief history of salivary gland surgery.
        Rev Col Bras Cir. 2017; 44 (Uma breve história da cirurgia das glândulas salivares): 403-412
        • Kochhar A.
        • Larian B.
        • Azizzadeh B.
        Facial nerve and parotid gland anatomy.
        Otolaryngol Clin North Am. 2016; 49: 273-284
        • Chiesa-Estomba C.M.
        • Larruscain-Sarasola E.
        • Lechien J.R.
        • et al.
        Facial nerve monitoring during parotid gland surgery: a systematic review and meta-analysis.
        Eur Arch Otorhinolaryngol. 2021; 278: 933-943
        • Ord R.A.
        • Ghazali N.
        Margin analysis: malignant salivary gland neoplasms of the head and neck.
        Oral Maxillofac Surg Clin North Am. 2017; 29: 315-324
        • Terhaard C.
        • Lubsen H.
        • Tan B.
        • et al.
        Facial nerve function in carcinoma of the parotid gland.
        Eur J Cancer. 2006; 42: 2744-2750
        • Terakedis B.E.
        • Hunt J.P.
        • Buchmann L.O.
        • et al.
        The prognostic significance of facial nerve involvement in carcinomas of the parotid gland.
        Am J Clin Oncol. 2017; 40: 323-328
        • Guntinas-Lichius O.
        • Klussmann J.P.
        • Schroeder U.
        • et al.
        Primary parotid malignoma surgery in patients with normal preoperative facial nerve function: outcome and long-term postoperative facial nerve function.
        Laryngoscope. 2004; 114: 949-956
        • National Comprehensive Cancer Network
        Clinical Practice Guidelines in Oncology. Version 1.2020.
        (Available at:) (Accessed May 8, 2020)
        • Moss W.J.
        • Coffey C.S.
        • Brumund K.T.
        • et al.
        What is the role of elective neck dissection in low-, intermediate-, and high-grade mucoepidermoid carcinoma?.
        Laryngoscope. 2016; 126: 11-13
        • Harbison R.A.
        • Gray A.J.
        • Westling T.
        • et al.
        The role of elective neck dissection in high-grade parotid malignancy: a hospital-based cohort study.
        Laryngoscope. 2020; 130: 1487-1495
        • Mendenhall W.M.
        • Morris C.G.
        • Amdur R.J.
        • et al.
        Radiotherapy alone or combined with surgery for salivary gland carcinoma.
        Cancer. 2005; 103: 2544-2550
        • Terhaard C.H.
        • Lubsen H.
        • Rasch C.R.
        • et al.
        The role of radiotherapy in the treatment of malignant salivary gland tumors.
        Int J Radiat Oncol Biol Phys. 2005; 61: 103-111
        • Bakst R.L.
        • Su W.
        • Ozbek U.
        • et al.
        Adjuvant radiation for salivary gland malignancies is associated with improved survival: a National Cancer Database analysis.
        Adv Radiat Oncol. 2017; 2: 159-166
        • Schmitt N.C.
        • Kang H.
        • Sharma A.
        Salivary duct carcinoma: an aggressive salivary gland malignancy with opportunities for targeted therapy.
        Oral Oncol. 2017; 74: 40-48
        • Chiosea S.I.
        • Williams L.
        • Griffith C.C.
        • et al.
        Molecular characterization of apocrine salivary duct carcinoma.
        Am J Surg Pathol. 2015; 39: 744-752
        • Thorpe L.M.
        • Schrock A.B.
        • Erlich R.L.
        • et al.
        Significant and durable clinical benefit from trastuzumab in 2 patients with HER2-amplified salivary gland cancer and a review of the literature.
        Head & neck. 2017; 39: E40-E44
        • Shin D.S.
        • Sherry T.
        • Kallen M.E.
        • et al.
        Human epidermal growth factor receptor 2 (HER-2/neu)-directed therapy for rare metastatic epithelial tumors with HER-2 amplification.
        Case Rep Oncol. 2016; 9: 298-304